HGH Wholesale
Human Growth Hormone (somatropin) — 191-amino acid central regulator of the GH/IGF-1 axis, batch-documented, manufacturer-direct
Product Identity
| CAS Number | 12629-01-5 |
| Sequence | 191-amino acid polypeptide with 2 disulfide bonds (Cys⁵³-Cys¹⁶⁵, Cys¹⁸²-Cys¹⁸⁹) |
| Molecular Formula | C₉₉₀H₁₅₂₈N₂₆₂O₃₀₀S₇ |
| Molecular Weight | ~22,125 Da |
| Isoelectric Point | ~5.2 |
| Appearance | White to off-white lyophilized powder |
| Purity | ≥99% by HPLC |
| Solubility | Sterile water or bacteriostatic water; gentle swirling |
| Storage | 2–8°C (lyophilized); use promptly after reconstitution |
Available Configurations
| Kit | Content per Vial | Total IU | Best For |
|---|---|---|---|
| 100 IU Kit | 10 IU (~3.3mg) × 10 vials | 100 IU | Evaluation; small-scale research |
| 150 IU Kit | 15 IU (~5mg) × 10 vials | 150 IU | Medium-scale protocols |
| 200 IU Kit | 20 IU (~6.7mg) × 10 vials | 200 IU | High-throughput; bulk research |
| Custom | Custom IU × custom vials | Custom | OEM; specific protocols |
Research Background
Human Growth Hormone is a 191-amino acid, single-chain polypeptide synthesized by somatotroph cells in the anterior pituitary. It is the primary regulator of postnatal somatic growth and a key metabolic hormone — controlling the GH/IGF-1 axis via hypothalamic GHRH (+) and somatostatin (-) regulation.
Physiological Roles
| System | GH Effect | Mechanism |
|---|---|---|
| Skeletal System | Linear bone growth (pre-pubertal); ↑ BMD | IGF-1 → chondrocyte & osteoblast stimulation |
| Skeletal Muscle | ↑ protein synthesis; ↑ lean body mass | IGF-1 + direct GH amino acid transport effects |
| Adipose Tissue | ↑ lipolysis; ↓ lipogenesis | Direct GH receptor activation on adipocytes |
| Liver | IGF-1 production; ↑ gluconeogenesis | GH→JAK-STAT→IGF-1 transcription |
| Carbohydrate Metab. | Insulin resistance (counter-regulatory) | GH reduces insulin-stimulated glucose uptake |
Research Focus Areas
GH effects on lean mass, fat mass, bone density
Anabolic signaling; fractional synthetic rate
Age-related GH decline (somatopause); IGF-1 models
Lipolytic effects; insulin sensitivity modulation
GH effects on tissue repair; collagen synthesis
HGH vs Growth Hormone Secretagogues (GHS)
| Aspect | HGH (Direct) | GHS (e.g. CJC-1295) |
|---|---|---|
| Mechanism | Direct GH receptor activation | Stimulate pituitary GH release |
| Molecular Target | GHR on target tissues | GHRH-R or GHS-R1a on pituitary |
| IGF-1 Response | Direct | Indirect (via stimulated GH) |
| Dose Control | Precise — exogenous | Variable — pituitary-dependent |
| Research Use | Direct GH effects | Endogenous GH axis regulation |
| Pulsatility | Supraphysiological, non-pulsatile | Preserves/enhances pulsatile pattern |
| PSH Availability | ✓ | ✓ (Muscle Growth category) |
Quality Specifications
| Parameter | Method | Criterion |
|---|---|---|
| Purity (HPLC) | RP-HPLC, C18 | ≥99.0% peak area |
| Identity (MW) | ESI-MS / MALDI-TOF | ~22,125 ± 5.0 Da |
| Appearance | Visual | White to off-white powder |
| Protein Content | UV A₂₈₀ / Bradford | ≥90% of labeled content |
| Purity (SDS-PAGE) | Reducing SDS-PAGE | Single band at ~22 kDa (bulk orders) |
| Residual Moisture | Karl Fischer | ≤3% |
| Endotoxin | LAL assay | ≤1.0 EU/mg (on request) |
HGH quality analysis combines RP-HPLC, mass spectrometry, and SDS-PAGE — all three applied to ensure research-grade quality for this 22 kDa protein.
Tiered Wholesale Pricing
| Volume | Discount | For |
|---|---|---|
| 1 kit | List price | Evaluation; protocol validation |
| 2–5 kits | 10–20% off | Small groups; initial stocking |
| 6–20 kits | 25–40% off | Mid-size distributors |
| 21–50 kits | 40–55% off | Regional distributors |
| 50+ kits | 55–70% off | Large distributors; recurring |
FAQ
What's the difference between HGH and GHS peptides (CJC-1295, Ipamorelin)?
HGH directly activates GH receptors on target tissues and stimulates IGF-1. GHS peptides (CJC-1295, Ipamorelin) stimulate pituitary release of endogenous GH. For direct GH receptor studies: use HGH. For GH axis regulation studies: use GHS peptides. In body composition research, HGH gives precise dose control; GHS peptides produce more physiological but less controllable responses.
How should HGH be reconstituted and stored?
Reconstitute with sterile or bacteriostatic water — add diluent gently down vial wall, don't squirt onto powder. Swirl gently (never shake or vortex — denatures protein). Store reconstituted at 2–8°C, use within 7–14 days. Never freeze-thaw — causes aggregation and bioactivity loss.
Which kit size should I order?
Rodent research: 100 IU kit (10 IU vials) for weight-based dosing. Larger animal models or high-concentration cell culture: 150 IU or 200 IU kits. Uncertain? Start with 100 IU evaluation. Contact us — share your model and we'll recommend the right configuration.
How do you verify it's actually intact HGH and not a fragment?
Three methods: (1) Mass spectrometry confirms MW ~22,125 Da ±5 Da — a fragment would show different mass. (2) SDS-PAGE shows single band at ~22 kDa — multiple bands = impurities or degradation. (3) RP-HPLC confirms ≥99% single-peak purity. All three in our QC release testing for research-grade HGH.
FOR LABORATORY RESEARCH USE ONLY. Not for human or veterinary diagnostic, therapeutic, or clinical use. HGH is a controlled substance in some jurisdictions — buyers are responsible for verifying the legal status of importation and possession in their country.
Ready to Source HGH?
Three kit configurations. Tiered pricing up to 70%. Full analytical QC: MS + SDS-PAGE + HPLC with every bulk order.