Nootropic & Anti-Aging Peptides
Cognitive enhancement & longevity research — factory-direct, batch-traceable
Key Statistics
The nootropic and anti-aging category spans peptides that target neural plasticity, sleep regulation, and cellular senescence — three axes of longevity research. Semax is the most characterized nootropic peptide in the literature, with documented effects on BDNF expression and neuroprotection. Epithalon targets telomerase activation pathways implicated in replicative lifespan extension. Our team is particularly experienced with these two peptides — their synthesis requires precise deprotection protocols to maintain C-terminal amidation integrity.
Product Specifications
| Product | CAS | MW (Da) | Research Context | Std. Configuration |
|---|---|---|---|---|
| Semax | 80714-61-0 | 813.9 | ACTH(4–7)-Pro-Gly-Pro — BDNF upregulation, neuroprotection | 10 mg × 10 vials |
| Selank | 129954-34-1 | 751.9 | Tuftsin-derived — anxiolytic, immune-neural modulation | 10 mg × 10 vials |
| Epithalon | 307297-39-8 | 390.4 | Ala-Glu-Asp-Gly — telomerase activation, pineal peptide | 10 mg × 10 vials |
| DSIP | 62568-57-4 | 848.8 | Delta sleep-inducing peptide — sleep architecture | 5 mg × 10 vials |
| FOXO4-DRI | — | 4,316.0 | FOXO4-p53 interaction inhibitor — senolytic | 5 mg × 10 vials |
Pathway Targets
Neurotrophin upregulation → enhanced synaptic plasticity
Anxiolytic without sedation → immune-neural bridge
Telomere maintenance → replicative lifespan extension
Delta wave promotion → restorative sleep regulation
p53-mediated senescent cell clearance
FAQ
What is the research evidence for Epithalon and telomerase?
Epithalon (Ala-Glu-Asp-Gly) has been studied for its effect on telomerase activity in somatic cells. Research by Khavinson et al. documented telomere length preservation in cell cultures treated with the tetrapeptide, implicating gene expression modulation of telomerase catalytic subunit hTERT. This remains an active area of biogerontology research.
How does Semax differ from Selank?
Semax is an ACTH(4–7) fragment modified with a C-terminal Pro-Gly-Pro tripeptide that enhances metabolic stability. Its primary documented mechanism is BDNF/NGF upregulation. Selank is a tuftsin-derived heptapeptide that modulates GABAergic and dopaminergic systems — producing an anxiolytic profile without sedation. They are complementary but mechanistically distinct.
What is FOXO4-DRI?
FOXO4-DRI (D-Retro-Inverso) is a modified peptide that disrupts the FOXO4-p53 interaction in senescent cells — a mechanism for targeted senescent cell clearance (senolysis). It represents a fundamentally different approach from the signaling peptides in this category: rather than modulating a pathway, it targets a specific protein-protein interaction.
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